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Related Experiment Videos

Salmonella sepsis in infancy

R C Davis

    American Journal of Diseases of Children (1960)
    |December 1, 1981
    PubMed
    Summary
    This summary is machine-generated.

    Salmonella infections, including sepsis and meningitis, are a significant concern in infants under one year old. Chloramphenicol-based treatments show better efficacy for Salmonella meningitis in infants than ampicillin alone.

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    Area of Science:

    • Pediatric Infectious Diseases
    • Neonatal Sepsis and Meningitis
    • Microbiology and Epidemiology

    Background:

    • Salmonella infections pose a serious threat to infants, particularly those under one year of age.
    • Neonatal sepsis and meningitis are severe complications of Salmonella infections in young infants.
    • Understanding the incidence and treatment outcomes of Salmonella in this vulnerable population is crucial.

    Observation:

    • A review of cases in Arkansas revealed 383 Salmonella infections in infants under one year over 3.5 years.
    • The incidence of sepsis and/or meningitis was 1.8% overall, rising to 5.0% in infants less than two months old.
    • Epidemiologic studies did not identify a consistent source for Salmonella colonization in young infants.

    Findings:

    • Treatment of Salmonella meningitis with ampicillin sodium was often linked to relapse or treatment failure.

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  • Chloramphenicol, or a combination of chloramphenicol and ampicillin, demonstrated superior efficacy in treating Salmonella meningitis.
  • Ampicillin sodium treatment failure in Salmonella meningitis highlights the need for alternative therapeutic strategies.

    • Implications:

    • Consideration of routine antibiotic treatment for Salmonella gastroenteritis in infants under three months is recommended.
    • The findings suggest a need for revised treatment guidelines for Salmonella infections in neonates and young infants.
    • Further research into the sources of Salmonella colonization in infants may help in developing preventative measures.