Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Length-dependent sensitivity in vascular smooth muscle

J M Price, D L Davis, E B Knauss

    The American Journal of Physiology
    |October 1, 1981
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    The effect of time from surgery to commencing adjuvant radiotherapy for patients with head and neck squamous cell carcinoma.

    Oral oncology·2024
    Same author

    Preliminary study on the impact of 900 MHz radiation on human sperm: An in vitro molecular approach.

    Reproductive toxicology (Elmsford, N.Y.)·2024
    Same author

    Improved survival prediction for oropharyngeal cancer beyond TNMv8.

    Oral oncology·2021
    Same author

    Absorption of wireless radiation in the child versus adult brain and eye from cell phone conversation or virtual reality.

    Environmental research·2018
    Same author

    Randomized, Controlled, Crossover trial of Prevention of Clindamycin-Induced Gastrointestinal Signs Using a Synbiotic in Healthy Research Cats.

    Journal of veterinary internal medicine·2017
    Same author

    Single-fraction Radiotherapy Should be the Standard of Care for Palliation of Cancer Symptoms in Patients with Limited Life Expectancy.

    Clinical oncology (Royal College of Radiologists (Great Britain))·2017
    Same journal

    Blood coagulation in fish.

    The American journal of physiology·2011
    Same journal

    Renal tubular reabsorption, metabolic utilization and isomeric fractionation of lactic acid in the dog.

    The American journal of physiology·2010
    Same journal

    The inactivation of placental toxin by human serum.

    The American journal of physiology·2010
    Same journal

    Adrenal function following ovariectomy in the rat.

    The American journal of physiology·2010
    Same journal

    Capillary permeability; perfusion of frog and guinea pig hind limbs.

    The American journal of physiology·2010
    Same journal

    Evaluation of protective measures against sunburn.

    The American journal of physiology·2010
    See all related articles

    Vascular smooth muscle sensitivity to norepinephrine and potassium depends on arterial length, similar to active tension. This length-dependent sensitivity is consistent across different stimulation methods.

    Area of Science:

    • Physiology
    • Pharmacology
    • Biophysics

    Background:

    • Vascular smooth muscle tone is crucial for regulating blood pressure.
    • The relationship between vascular smooth muscle length and active tension is well-established.
    • However, how arterial circumference influences vascular smooth muscle sensitivity to stimuli is less understood.

    Purpose of the Study:

    • To investigate if vascular smooth muscle sensitivity to norepinephrine (NE) and potassium (K+) is dependent on arterial length (circumference).
    • To compare the length-sensitivity relationship with the known length-active tension relationship in vascular smooth muscle.

    Main Methods:

    • Dose-response curves were generated for NE and K+ on dog anterior tibial artery rings.
    • Artery rings were tested at various lengths (L), including the length for maximum active force (Lmax).

    Related Experiment Videos

  • The dose for half-maximal response (ED50) was determined using graphical estimation and curve fitting.

    • Main Results:

    • Vascular smooth muscle sensitivity (lower ED50) was highest at Lmax and decreased significantly as length decreased from Lmax.
    • Sensitivity did not significantly differ between Lmax and 1.15 Lmax.
    • Repeated measurements at Lmax showed consistent sensitivity, and reversing length changes reversed sensitivity changes.

    Conclusions:

    • Vascular smooth muscle sensitivity to NE and K+ is dependent on arterial length.
    • The observed length-sensitivity relationship mirrors the length-active tension relationship.
    • This length-dependent sensitivity is independent of the stimulation method (NE vs. K+).