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Related Experiment Videos

Nitrous oxide elimination by the newborn

E Mankowitz, J G Brock-Utne, J W Downing

    Anaesthesia
    |November 1, 1981
    PubMed
    Summary
    This summary is machine-generated.

    Nitrous oxide elimination was studied in infants born via Caesarean section. Detected levels in neonates were generally too low for significant diffusion hypoxia, but caution is advised.

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    Area of Science:

    • Anesthesiology
    • Neonatal Medicine
    • Pharmacokinetics

    Background:

    • Nitrous oxide is commonly used in obstetric anesthesia.
    • Understanding neonatal exposure and elimination is crucial for infant safety.

    Purpose of the Study:

    • To investigate the elimination of nitrous oxide in neonates following maternal exposure during Cesarean section.
    • To assess the risk of diffusion hypoxia in these infants.

    Main Methods:

    • Studied ten infants whose mothers received 50% nitrous oxide and enflurane during Cesarean section.
    • Measured nitrous oxide concentration in end-expired gas of neonates.

    Main Results:

    • Nitrous oxide levels in infant end-expired gas ranged from 1 to 4 vol%, with a mean of 1.9 vol%.

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  • These concentrations were deemed too low to cause significant diffusion hypoxia in healthy neonates.

    • Conclusions:

    • While generally safe, a small subset of infants might be affected by nitrous oxide exposure.
    • Recommend administering oxygen-enriched air to neonates exposed to maternal nitrous oxide anesthesia.