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[Convulsive seizures and polyneuritis in a patient with lupus treated with metronidazole (author's transl)]
Abstract:
A 20-year-old patient with biologically-confirmed lupus developed a perirenal abscess following puncture biopsy of the kidney. Postoperative treatment included metronidazole at a mean dose of 2.5 g daily for 68 days (total dose : 165 g). Generalised convulsive seizures occurred on four occasions, associated with paresthesia of the four limbs, but without loss of motor or reflex activity, though some distal hypoesthesia was detected. An acute lupus attack was eliminated, the convulsive seizures not recurring after discontinuation of treatment, and the paresthesias diminishing progressively over a period of three months. Electrical investigations showed lack of motor anomalies but a marked reduction in sensory conduction. This is the 13th reported case of polyneuritis due to metronidazole, the 4th case of convulsive seizures, and the first case in which both manifestations occurred. The plasma concentration curve after oral administration of 1 g of the product to this patient demonstrated that the product was not being metabolised in a pathological manner.
Insights
Metronidazole, an antibiotic, can cause neurological side effects like seizures and polyneuropathy in lupus patients. This case highlights the importance of monitoring for these adverse events during prolonged treatment.
Area of Science:
- Nephrology
- Neurology
- Pharmacology
Background:
- A 20-year-old lupus patient developed a perirenal abscess post-kidney biopsy.
- Treatment involved high-dose, long-term metronidazole (165g total).
Observation:
- The patient experienced four episodes of generalized convulsive seizures with limb paresthesia.
- Neurological examination revealed sensory conduction deficits but no motor anomalies.
Findings:
- This is the first reported case of both metronidazole-induced polyneuritis and convulsive seizures occurring together.
- Seizures ceased and paresthesias improved after discontinuing metronidazole.
- Metronidazole metabolism was not pathologically altered.
Implications:
- Metronidazole can cause significant neurological toxicity, including seizures and polyneuropathy, even with normal metabolism.
- Clinicians should be vigilant for these adverse effects in patients on prolonged or high-dose metronidazole therapy.
- Early recognition and discontinuation of the drug are crucial for recovery.