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Related Experiment Videos

Glycopyrrolate in children

P Warran, P Radford, M L Manford

    British Journal of Anaesthesia
    |December 1, 1981
    PubMed
    Summary
    This summary is machine-generated.

    Intravenous glycopyrrolate effectively reduced secretions during anesthesia compared to oral or intravenous atropine. Oral atropine increased secretions and cardiac arrhythmias, while IV glycopyrrolate offered superior antisialagogue effects.

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    Area of Science:

    • Anesthesiology
    • Pharmacology

    Background:

    • Antisialagogue medications are crucial for managing secretions during anesthesia.
    • Atropine and glycopyrrolate are commonly used, but their efficacy and side effect profiles differ based on administration route and timing.

    Purpose of the Study:

    • To compare the antisialagogue effects and side effects of intravenous glycopyrrolate versus intravenous and oral atropine.
    • To evaluate the impact on body temperature, heart rate, cardiac arrhythmias, and postoperative restlessness.

    Main Methods:

    • A comparative study involving three groups of patients undergoing anesthesia.
    • Group 1: Intravenous glycopyrrolate (10 µg/kg) at induction.
    • Group 2: Intravenous atropine (20 µg/kg) at induction.
    • Group 3: Oral atropine (30 µg/kg) 90 minutes before operation.

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  • Measurements included pharyngeal secretions, axillary temperature, heart rate, cardiac arrhythmia frequency, and postoperative restlessness.

    • Main Results:

    • Patients receiving oral atropine experienced increased pharyngeal secretions, lower heart rates, and a higher frequency of cardiac arrhythmias compared to intravenous administration.
    • Intravenous glycopyrrolate demonstrated significantly reduced intraoperative secretions.
    • No significant differences were noted in body temperature or postoperative restlessness between the groups.

    Conclusions:

    • Intravenous glycopyrrolate is a more effective antisialagogue agent during anesthesia than oral or intravenous atropine.
    • Oral atropine administration is associated with increased secretions and a higher incidence of cardiac arrhythmias, suggesting potential risks.