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Abstract:
Sensitivity of two kinds of spiral wave sources of excitation of fast inward current (INa) inhibition was compared. These spiral wave sources were: circulation in a ring around an obstacle--re-entry and circulation in tissue without an obstacle--reverbarator (leading circle). It was shown that moderate inhibition of INa ceased the circulation of the reverbarator but was ineffective against the circulation in the ring. It is known that auricular flutter and fibrillation are based on wave circulation in the ring. So a conclusion was made that all antiarrhythmic drugs inhibiting mainly the sodium current should be ineffective against auricular flutter and fibrillation.