[Transformation of enzyme graphs having the form of a multidimensional parallelepiped]

The graph of an enzymic reaction having the form of a multidimensional parallelepiped with equal opposite sides may be substituted, as shown, by consideration of n separate unidimensional subgraphs, which simplifies significantly the procedure of derivation of steady-state relations. The applications of this method to derivation of steady-state rate equation for a two-substrate reaction with random addition mechanism and to generalization of the Monod et al. model for multisubstrate reactions have been considered.