[Kinetics of lipid peroxidation in cell organelles which have sustained anoxia under various conditions]

Kinetics of LPO in cellular organelles - mitochondrial, microsomal, lysosomal and nuclear fractions, which were subject to intertissue or extratissue anoxia were studied under incubation at 37 degrees C. Intertissue anoxia causes the strengthening of LPO in all cellular organelles, while anoxia of organelles after extraction from tissue causes it only in mitochondrial fraction. A higher level of LPO, the earlier reaching of its maximum in mitochondrial fractions compared with other organelles shows their highest sensitivity to intratissue and extratissue anoxia and their susceptibility to oxidation destruction. Products of LPO extracted by mitochondrial fractions evidently can provoke LPO in other organelles, under intertissue anoxia.