[Effect of clonidine and naloxone in somatovegetative responses in decerebrate cats]

Experiments on decerebrated curarized cats were performed to study changes in the basal level of arterial pressure, cardiac output and blood flow in the common iliac artery, as well as hemodynamic reactions induced by the central command to the skeletal muscles during fictitious scratching after administration of clonidine in a dose of 30 microgram/kg and naloxone in a dose of 0.12-0.15 microgram/kg. Clonidine decreased the blood flow in the iliac artery, exerting a negligible effect on other hemodynamic parameters. The pressor reaction of arterial pressure during the central command to the skeletal muscles decreased by 8 mm Hg under the effect of clonidine, while the appearance of the activity periods in the gastrocnemius nerve was facilitated and increased. Naloxone administered in the presence of clonidine elevated arterial pressure by 14 mm Hg, having no effect on evoked responses on the part of the cardiovascular system.