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Related Experiment Videos

Pig-bel--a zoonosis?

T G Murrell, P D Walker

    The Journal of Tropical Medicine and Hygiene
    |November 1, 1978
    PubMed
    Summary
    This summary is machine-generated.

    A low protein diet and sweet potato trypsin inhibitors can cause inadequate digestion, leading to gangrene when consuming meat contaminated with Clostridium perfringens type C. Prevention involves a toxoided vaccine.

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    Area of Science:

    • Gastroenterology
    • Microbiology
    • Nutritional Science

    Background:

    • Clostridium perfringens type C causes necrotizing enteritis.
    • Dietary factors, including low protein and trypsin inhibitors, may influence disease susceptibility.

    Purpose of the Study:

    • To investigate the role of diet in C. perfringens type C-induced enteritis.
    • To understand the pathogenesis of segmental gangrene linked to dietary conditions and C. perfringens type C.

    Main Methods:

    • Postulated a model involving low protein diet, low tryptic activity, and sweet potato trypsin inhibitors.
    • Described the pathogenic process initiated by beta toxin and C. perfringens type C colonization.

    Main Results:

    • Inadequate proteolysis occurs under specific dietary conditions when consuming contaminated meat.

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  • Beta toxin causes motor paralysis, facilitating C. perfringens type C gut colonization and necrobiosis.

    • Conclusions:

    • Dietary factors significantly influence susceptibility to C. perfringens type C infection and disease.
    • Pigs may act as carriers, with humans as incidental hosts under specific small gut ecological conditions.
    • A toxoided vaccine offers short-term prevention.