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Updated: Jul 22, 2026

10:44
Mass Spectrometry and Luminogenic-based Approaches to Characterize Phase I Metabolic Competency of In Vitro Cell Cultures
Published on: March 28, 2017
Quantitative analysis of purine and pyrimidine metabolism in Chinese hamster ovary cells
Abstract:
A detailed quantitative study of purine and pyrimidine metabolism in logarithmically growing Chinese hamster ovary cells has been performed. Direct measurements of the ribonucleoside and deoxyribonucleoside triphosphate pool sizes have been made, and the pathways and rates of metabolism of adenine, hypoxanthine, guanine, guanosine, deoxyadenosine, and deoxyguanosine and of uridine, cytidine, deoxycytidine, deoxyuridine, and thymidine have been determined.

