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Polypsychopharmacy revisited

M S Rapp, A Kaplan

    Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie
    |December 1, 1981
    PubMed
    Summary
    This summary is machine-generated.

    Polypsychopharmacy, or the use of multiple psychiatric medications, is common but lacks sufficient research. This study challenges assumptions against two-drug combinations, suggesting more research is needed.

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    Area of Science:

    • Psychiatry
    • Pharmacology
    • Medical Literature Analysis

    Background:

    • Polypsychopharmacy, the concurrent use of multiple psychiatric medications, is prevalent.
    • Existing medical literature often displays hostility towards two-drug combinations in psychiatry.
    • This hostility is frequently based on unsubstantiated assumptions regarding drug interactions and efficacy.

    Purpose of the Study:

    • To define polypsychopharmacy and analyze its incidence rates.
    • To critically evaluate the medical literature's assumptions regarding two-drug combinations in psychiatric treatment.
    • To explore reasons for the lack of research and persistent use of polypsychopharmacy.

    Main Methods:

    • Literature review and analysis of definitions and incidence rates of polypsychopharmacy.

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  • Examination of assumptions underpinning the negative stance on two-drug combinations in psychiatric literature.
  • Identification of valuable two-drug combinations in psychiatric practice.

    • Main Results:

    • Incidence rates of polypsychopharmacy are not solely dependent on physician behavior.
    • Little evidence supports the common negative assumptions about two-drug combinations in psychiatry.
    • Several valuable two-drug combinations in psychiatry were identified.

    Conclusions:

    • Attempts to reduce polypsychopharmacy incidence may be ineffective without addressing underlying issues.
    • The lack of research into widely used two-drug combinations is notable.
    • Further research into specific drug combinations in psychiatry is urgently needed, as their value is comparable to other medical fields.