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Related Experiment Videos

"T's and B's"-Midwestern heroin substitute

M L De Bard, J A Jagger

    Clinical Toxicology
    |September 1, 1981
    PubMed
    Summary

    Street drug "T's and B's," a pentazocine and tripelennamine combination, is a heroin substitute causing abscesses, drug reactions, and seizures. This study details the adverse health effects observed in patients using this illicit combination.

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    Area of Science:

    • Toxicology
    • Pharmacology
    • Public Health

    Background:

    • Emergence of
    • T's and B's
    • (pentazocine and tripelennamine) as a significant intravenous drug substitute for heroin, particularly in the Midwestern United States.

    Observation:

    • A retrospective review of 104 cases involving 82 patients over nine months at St. Elizabeth Medical Center in Dayton, Ohio.
    • Documented adverse events including abscesses and cellulitis (39%), characteristic drug reactions (38%), seizures, syncope, and near-syncope (15%).
    • Observed a previously described pulmonary reaction (38%) and chest pain syndrome (4%).

    Findings:

    • High incidence of injection site infections such as abscesses and cellulitis.
    • Frequent systemic adverse effects including neurological (seizures, syncope) and psychiatric symptoms (agitation, anxiety).
    • Significant prevalence of pulmonary and cardiovascular symptoms associated with drug use.

    Implications:

    • Highlights the severe health risks associated with the non-medical use of pentazocine and tripelennamine.
    • Underscores the need for increased awareness among healthcare providers regarding this drug combination and its complications.
    • Informs public health strategies aimed at harm reduction and intervention for intravenous drug users.

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