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Coronary atherosclerosis in Aligarh district, Uttar Pradesh. A morphological study
Japanese Circulation Journal
|September 1, 1978
Summary
Atherosclerotic lesions in coronary arteries are common, appearing early and progressing with age. Indians show slower plaque progression and fewer complicated lesions compared to other populations.
Area of Science:
- Cardiovascular Pathology
- Atherosclerosis Research
Background:
- Atherosclerosis is a significant cardiovascular disease.
- Understanding lesion progression is crucial for public health.
Purpose of the Study:
- To investigate the type and extent of atherosclerotic lesions in coronary arteries.
- To analyze the natural history and histomorphological changes of these lesions.
- To compare lesion development in Indians with general population data.
Main Methods:
- Analysis of 108 heart specimens.
- Evaluation of lesion type, extent, and intimal surface involvement.
- Histomorphological and degenerative change assessment.
Main Results:
- Atherosclerotic lesions were present in 81.4% of cases.
- Fatty streaks appeared in the 2nd decade, progressing to involve 26% of the surface by the 6th decade.
- Fibrous plaques and complicated lesions showed slower progression in Indians, with a lower incidence of complicated lesions.
- Left coronary artery involvement (79.62%) was slightly higher than the right (72.22%).
Conclusions:
- Atherosclerotic lesions are highly prevalent, with early onset and age-related progression.
- Indians exhibit a distinct natural history of atherosclerosis, characterized by slower fibrous plaque progression and reduced complicated lesion incidence.
- Significant differences exist in lesion prevalence between coronary arteries and the aorta.