Growth inhibition and morphologic modulation of human fibroblastlike cells by erythromycin

In vitro exposures of mass cultures and clones of human diploid fibroblastlike cells to erythromycin, in concentrations of 50 to 400 micrograms/ml, results in increasing degrees of growth inhibition and augmented cell volume, with a shift toward larger proportions of cells of the epithelioid type and fewer of the fibroblast type. These alterations were reversed upon subculture in the absence of the antibiotic.