Circadian rhythmicity of prolactin secretion in elderly subjects: changes during bromocriptine treatment

Prolactin has been taken as an index of neuroendocrine function in aging, where dopaminergic neurotransmission in considered to be impared. The mean concentration of the hormone in the 24 h is higher in the aged men than in the adult controls. A sleep entrained periodicity is present in both aged subjects and controls, but a harmonic analysis of rhythmicity shows that secretory episodes have in aged men a slower periodicity than in adults. In aged men bromocriptine decreases the mean PRL values in the 24 h and the periodicity analysis shows the occurrence of harmonics with shorter period.