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Immunological responsiveness and adjunct immunotherapy in lung cancer
The Japanese Journal of Surgery
|December 1, 1978
Summary
This study assessed immunocompetency in lung cancer patients, finding immune responses correlate with clinical stage. Postoperative immune function improved in resectable cases but declined in unresectable or recurrent lung cancer.
Area of Science:
- Oncology
- Immunology
- Surgical Oncology
Background:
- Lung cancer significantly impacts patient immunocompetency.
- Assessing immune status is crucial for treatment planning and prognosis.
Purpose of the Study:
- To evaluate changes in immunocompetency before and after surgery in lung cancer patients.
- To correlate immune response with clinical stage and treatment outcomes.
Main Methods:
- Assessed immune status using skin tests (PPD, DNCB), lymphocyte response to PHA, T-cell proportion, macrophage migration inhibition test (MIT), and blocking factor.
- Evaluated 40 patients with lung cancer.
Main Results:
- Macrophage migration inhibition test (MIT) was positive in 27%, and blocking factor in 42% of patients.
- Immune response correlated with the clinical stage of lung cancer.
- Postoperative immune response increased in curative resection cases but decreased in non-resectable or recurrent cases.
Conclusions:
- Immune status is a significant factor in lung cancer progression and treatment response.
- Findings support the potential for adjuvant specific immunotherapy in managing lung cancer.