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Related Experiment Videos

Neuronal membrane D2-protein during rat brain ontogeny

O S Jørgensen

    Journal of Neurochemistry
    |October 1, 1981
    PubMed
    Summary

    Sialylated D2-protein peaks during rat brain development, coinciding with neuronal migration and synaptogenesis. Its desialylated form appears postnatally, suggesting a role for D2-protein in neural development.

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    Area of Science:

    • Neuroscience
    • Developmental Biology
    • Biochemistry

    Background:

    • D2-protein exists in sialylated and desialylated forms.
    • These forms change during rat brain development from fetal to adult stages.

    Purpose of the Study:

    • Investigate concentrations and amounts of D2-protein forms during rat brain ontogeny.
    • Explore the role of D2-protein during neuronal migration and synaptogenesis.

    Main Methods:

    • Crossed immunoelectrophoresis was used.
    • Analysis was performed on forebrain and cerebellum during development.

    Main Results:

    • Sialylated D2-protein showed two peaks: one during neuronal migration (embryonic day 13/postnatal day 0) and another during synaptogenesis (postnatal day 6/20).
    • Desialylated D2-protein emerged postnatally, peaking around postnatal days 25 (forebrain) and 35 (cerebellum).

    Conclusions:

    • D2-protein's developmental expression patterns suggest a role in neuronal migration and synaptogenesis.
    • The distinct forms of D2-protein may function as adhesion molecules during brain development.

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