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Microchemical instrumentation

L Hood, M Hunkapiller, R Hewick

    Journal of Supramolecular Structure and Cellular Biochemistry
    |January 1, 1981
    PubMed
    Summary
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    Researchers developed novel microsequencing instruments for analyzing minute quantities of cell surface molecules. This advancement, alongside recombinant DNA technology, promises new opportunities in molecular analysis.

    Area of Science:

    • Biochemistry
    • Molecular Biology
    • Biotechnology

    Background:

    • Many crucial cell surface molecules are difficult to obtain in sufficient quantities for analysis.
    • Conventional methods and instrumentation are inadequate for analyzing trace amounts of these molecules.

    Purpose of the Study:

    • To develop new instrumentation for the sequence analysis of very small quantities of polypeptide chains.
    • To create advanced tools for the sequence analysis and synthesis of DNA molecules.

    Main Methods:

    • Development of two microsequenators using significantly less material than traditional sequenators.
    • Integration of new instrumentation with recombinant DNA techniques.

    Main Results:

    • Successful development of microsequencing instruments capable of analyzing minute polypeptide quantities.

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  • Advancement in instrumentation for DNA sequence analysis and synthesis.

    • Conclusions:

    • The new microsequencing and DNA analysis instrumentation offers powerful tools for studying cell surface molecules.
    • This technology, combined with recombinant DNA and hybridoma techniques, will enhance future cell-surface molecule analysis.