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[Attempts at postexposure active and passive human rabies immunization]

H Keller, R Hauser, A Wandeler

    Schweizerische Medizinische Wochenschrift
    |December 10, 1977
    PubMed
    Summary
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    New rabies vaccine protocols in Switzerland show efficacy with fewer injections. Combined active and passive vaccination did not inhibit antibody production, offering a potentially more convenient post-exposure prophylaxis.

    Area of Science:

    • Virology
    • Immunology
    • Vaccinology

    Context:

    • Current rabies post-exposure prophylaxis in Switzerland uses duck embryo vaccine with a 14-day injection schedule.
    • A new human diploid cell vaccine offers a potential alternative.
    • WHO guidelines recommend specific vaccination and booster schedules.

    Purpose:

    • To evaluate a reduced-injection schedule for a human diploid cell rabies vaccine.
    • To determine if combining active vaccination with human hyperimmune gamma-globulin affects antibody production.
    • To compare antibody titers achieved with different vaccination strategies.

    Summary:

    • A human diploid cell rabies vaccine was administered on days 0, 3, 7, 14, 28, and 90 to healthy volunteers.
    • One group received active vaccination only; the other received active vaccination plus human hyperimmune gamma-globulin.

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  • Both groups achieved adequate antibody titers (≥1:100) by day 14, with no significant inhibition observed in the combined group.

    • Impact:

    • Suggests a more convenient and potentially less burdensome rabies vaccination schedule is possible.
    • Indicates that combined active and passive immunization is a viable option for rabies post-exposure prophylaxis.
    • Supports the use of human diploid cell vaccines for effective rabies prevention.