[Suppression of Penicillium purpurogenum growth by organotin compounds]

We studied the effect of organotin compounds and their mixtures with N-cetylpyridinium chloride on the accumulation of biomass by Penicillium purpurogenum. Ditributylstannylic ester of fumaric acid at a concentration of 0.005 micrograms/ml was shown to inhibit the accumulation of biomass. If an organotin compound was used in combination with N-cetylpyridinium chloride, the fungicide effect was greater at a lower dose of the organotin compound in the mixture. Organotin compounds and their mixtures with N-cetylpyridinium chloride suppress protein biosynthesis in the fungal mycelium, increasing protein content in the cultural broth. The mechanism of action of organotin compounds on the growth of P. purpurogenum is discussed.