[Morphologic observations in liver damage in patients taking Depressan (dihydralazinum sulfuricum)]

Authors studied a 56 year old male and a 47 year old female patient having taken an antihypertonic drug for two and a half month and one year respectively observed acute HBsAg-negative liver disease. In the needle biopsy specimen obtained on the 8th day (at the male patient) and on the 10th day (at the female) of the onset of jaundice severe centrilobular liver cell necrosis was found, which in the first case was accompanied by "bridging" necrosis. In the necrosis-free areas hydropic and fatty degeneration of different degree and also cholestasis occurred. The mild local and portobiliar inflammatory reaction consisted of mononuclear cells, neutrophil- and eosinophil granulocytes. Pathogenetic role of the drug has been proved by a provocation test. Authors call attention to the fact, that Depressan represents another drug, being in use in this country, which causes centrilobular liver cell necrosis.