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Citrinin toxicity in growing chicks

T S Nelson, J N Beasley, L K Kirby

    Poultry Science
    |September 1, 1981
    PubMed
    Summary
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    Citrinin, a mycotoxin from Penicillium lanosum, negatively impacts broiler chick growth. High doses (330-440 ppm) significantly reduced body weight and feed utilization, with detectable citrinin in liver and blood.

    Area of Science:

    • Animal Science
    • Mycotoxicology
    • Poultry Nutrition

    Background:

    • Mycotoxins, such as citrinin, are common contaminants in animal feed.
    • Penicillium lanosum can produce citrinin on whole corn, posing a risk to poultry.
    • Understanding citrinin's toxicological effects is crucial for poultry health and productivity.

    Purpose of the Study:

    • To evaluate the effects of dietary citrinin on broiler chick growth performance.
    • To determine the toxicological impact of varying citrinin concentrations on broiler chicks.
    • To investigate the presence of citrinin in broiler tissues and blood.

    Main Methods:

    • Male broiler chicks were fed diets containing 0, 100, 220, 330, or 440 ppm citrinin for three weeks.
    • Body weight and feed utilization were measured throughout the study.

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  • Tissues (thigh muscle, kidney, liver) and blood were analyzed for citrinin presence.
  • Main Results:

    • Dietary citrinin significantly decreased body weight in broiler chicks at concentrations of 330 and 440 ppm.
    • An 8% reduction in average body weight was observed in chicks fed 220 ppm citrinin.
    • Feed utilization was impaired at 440 ppm citrinin, and detectable citrinin levels were found in the liver and blood of chicks fed this high dose.

    Conclusions:

    • Citrinin exposure negatively affects broiler chick growth and feed efficiency.
    • Even moderate levels of citrinin (220 ppm) can cause significant growth depression.
    • Citrinin can be absorbed and detected in broiler tissues and blood, indicating systemic toxicity.