Related Experiment Video
Updated: Aug 13, 2026

Capsular Serotyping of Streptococcus pneumoniae Using the Quellung Reaction
Published on: February 24, 2014
Immune response to a 14-valent pneumococcal polysaccharide vaccine in the elderly
Abstract:
A study was carried out in 24 elderly patients, aged 69 years or over, to determine the antibody response to and tolerance of a 14-valent pneumococcal polysaccharide vaccine. Patients were injected with 0.5 ml of the vaccine and blood samples were drawn before and 3 weeks afterwards. Antibody titres to 5 serotypes were measured by radioimmunoassay. The results showed that at least 92% of the patients had a 2-fold or greater antibody response (mean 5.1-fold increase or over). No systemic complaints were reported and after the first day only a few patients complained of erythema and/or soreness at the injection site.
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