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Uninhibited neurogenic bladder treated with Prazosin

D Jensen

    Scandinavian Journal of Urology and Nephrology
    |January 1, 1981
    PubMed
    Summary
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    Prazosin, an alpha-adrenoreceptor blocker, effectively treats urinary bladder hypermotility by increasing bladder capacity and reducing detrusor contractions in neurological patients. Long-term use also subjectively improves micturition for those with detrusor-sphincter dyssynergia.

    Area of Science:

    • Urology
    • Pharmacology
    • Neuroscience

    Background:

    • Urinary bladder hypermotility is a common issue in neurological conditions.
    • Current treatments for uninhibited neurogenic bladder have limitations.

    Purpose of the Study:

    • To investigate the efficacy of prazosin, a novel alpha-adrenoreceptor blocking agent, in managing urinary bladder hypermotility.
    • To assess the effects of prazosin on bladder capacity and detrusor activity in patients with neurological disorders.

    Main Methods:

    • Controlled cystometry was employed to evaluate bladder function.
    • Patients included those with normal bladders and uninhibited neurogenic bladders.
    • Both short-term and long-term administration of prazosin were studied.

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    Main Results:

    • Short-term prazosin administration significantly increased bladder capacity and diminished uninhibited detrusor contractions.
    • Long-term prazosin treatment led to subjective improvements in micturition for patients with detrusor-sphincter dyssynergia.
    • Cystometrograms indicated less pronounced improvements with long-term compared to short-term prazosin treatment.

    Conclusions:

    • Prazosin is a valuable therapeutic option for uninhibited neurogenic bladder.
    • The drug demonstrated a favorable side effect profile with few adverse events.
    • Prazosin offers a promising addition to the treatment armamentarium for bladder hypermotility.