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Platelet kinetics in systemic lupus erythematosus (SLE), with special reference to corticosteroid and azathioprine
Scandinavian Journal of Rheumatology
|January 1, 1981
Abstract:
Duplicate platelet survival studies were carried out on 10 patients with SLE. At the time of the first study 5 of them (group I) were untreated and the remaining 5 (group II) were receiving corticosteroid (CS) therapy. The second study was performed while group I patients received CS and group II patients CS + azathioprine (AT) treatment. Untreated SLE patients were shown to have normal values for platelet mean life-span (MLS) and platelet production rate. CS and AT treatment did not affect either platelet MLS or platelet production rate. The present study also provides further evidence that a state of compensated thrombocytolysis is not present in SLE.