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[State of guinea pig peripheral blood and bone marrow cells in phenol poisoning]
Tsitologiia I Genetika
|November 1, 1981
Abstract:
Blood tests and examination of bone marrow in 2-3 week guinea pigs under conditions of a long-term phenol intoxication (0.5 mg/kg perorally) showed the presence of thrombocytopenia and eosinophilia in peripheral blood and a decrease of the erythroblast maturation index in bone marrow. In the experiment with animals treated with a high dose of phenol there was an evidence of thrombocytopenia accompanied by reticulocytosis and a nuclear shift of neutrophils to the right. Erythroblast maturation index in bone marrow increase (the immature forms are quite probable to be formed due to ineffective division).