Intracerebral Ganglioneuroblastoma with intracytoplasmic microtubular aggregates: case report and ultrastructural...

Cerebral ganglioneuroblastoma is a rare entity that is not well characterized at the ultrastructural level. We report a case of such a neoplasm with some unique fine structural features. The tumor contains both small cells with little evidence of differentiation and large, bizarre multinucleate cells, many of which contain intracytoplasmic aggregates of 22- to 24-nm microtubules that displace the nucleus and cytoplasmic organelles to the periphery of the cell. Inclusions of this type have of previously been described in this entity.