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[Changes in serum lipoproteins in cerebrovascular disease (author's transl)]
Insights
Low high-density lipoprotein (HDL) cholesterol and unfavorable cholesterol ratios are key indicators for cerebrovascular disease risk. These lipid profile markers, including VLDL/HDL and LDL/HDL ratios, are significantly altered in patients with this condition.
Area of Science:
- Biochemistry
- Cardiovascular Medicine
- Epidemiology
Context:
- Cerebrovascular disease (CVD) poses a significant health burden globally.
- Lipid profiles, including cholesterol and triglycerides, are established risk factors for cardiovascular events.
- Specific lipoprotein ratios may offer enhanced predictive value for CVD risk assessment.
Purpose:
- To investigate differences in serum lipid profiles, specifically high-density lipoprotein (HDL) cholesterol, very low-density lipoprotein (VLDL)/HDL ratio, and low-density lipoprotein (LDL)/HDL ratio, between patients with cerebrovascular disease and a control population.
- To identify critical lipid parameters and ratios indicative of cerebrovascular disease risk.
Summary:
- A study of 96 patients with cerebrovascular disease revealed significant alterations in lipid profiles compared to controls.
- Low HDL levels (below 40 mg/dl) were observed in 50% of patients.
- Elevated VLDL/HDL (37.7%) and LDL/HDL (30.9%) ratios were common, even with cholesterol below 250 mg/dl and triglycerides below 175 mg/dl.
- Serum cholesterol and triglyceride levels alone were insufficient for risk detection in 44% of cases.
- HDL levels decrease with age in both sexes, with a notable decline between 40 and 80 years.
Impact:
- Identifies low HDL levels and unfavorable VLDL/HDL and LDL/HDL ratios as crucial risk indicators for cerebrovascular disease.
- Highlights the limitations of relying solely on total cholesterol and triglyceride levels for CVD risk assessment.
- Suggests that lipoprotein ratios provide more sensitive markers for identifying individuals at risk for cerebrovascular events.
Abstract:
The determination of serum cholesterol, triglycerides and lipoprotein cholesterol (VLDL, LDL and HDL) in 96 patients suffering from cerebral vascular disease showed that some parameters were significantly different from those recorded in a control population of corresponding age HDL values below 40 mg/dl were found in 50% of cases. Pathological LDH/HDL and VLDL/HDL ratios were found in 30.9% and 37.7%, respectively, of patients with cerebrovascular disease, whose serum cholesterol level was below 250 mg/dl and triglyceride level was 175 mg/dl. Only 56% of all patients had elevated serum cholesterol and/triglyceride and triglyceride alone does not detect the risk. The difference in the VLDL/HDL ratio in patients with cerebrovascular disease and that of the control population is highly significant. The HDL values and the VLDL/HDL ratio differ significantly, also. On average, the HDL levels in women are higher than those in men, but the decrease faster with increasing age. In both sexes a decrease in HDL level occurs between the age of 40 and 80. Low HDL levels and unfavourable LDL/HDL and VLDL/HDL quotients are important risk indicators for cerebrovascular disease.