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[Psychopathology of acute organophosphorus compound poisonings]
Abstract:
Under examination there were 65 patients with poisoning with organophosphorus insecticides (thiophos, carbophos, chlorophos). The leading psychotic symptoms in these intoxications were psychovegetative, psychovestibular and hyperkinetic ones, which transformed into each other, as the poisoning progressed. The therapeutic applications of atropine led to development of a drug psychosis resembling the oneiroid syndrome. While making the diagnostic differentiation between the latter and the psychosis due to the poisoning with organophosphorus insecticides one should take into account the clinical and laboratory findings.
Insights
Organophosphorus insecticide poisoning in 65 patients caused psychovegetative, psychovestibular, and hyperkinetic symptoms. Atropine treatment induced a drug psychosis, requiring careful differential diagnosis from the poisoning itself.
Area of Science:
- Toxicology
- Neuroscience
- Psychiatry
Context:
- Organophosphorus insecticides (OPs) are widely used pesticides.
- OP poisoning can lead to severe neurological and psychiatric manifestations.
- Differential diagnosis is crucial for effective treatment.
Purpose:
- To describe the clinical presentation of psychotic symptoms in organophosphorus insecticide poisoning.
- To analyze the development of drug-induced psychosis following atropine therapy.
- To highlight key differences for diagnostic differentiation.
Summary:
- Sixty-five patients with organophosphorus insecticide (thiophos, carbophos, chlorophos) poisoning were studied.
- Key symptoms included evolving psychovegetative, psychovestibular, and hyperkinetic syndromes.
- Atropine treatment precipitated a psychosis resembling oneiroid syndrome, necessitating clinical and laboratory-based differential diagnosis.
Impact:
- This study aids clinicians in distinguishing between OP-induced psychosis and atropine-induced psychosis.
- Understanding these distinctions is vital for appropriate patient management and treatment.
- Highlights the complex neurotoxic and iatrogenic effects of organophosphorus compounds.