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Enzyme studies and neonatal brain damage

B Dalens, J L Viallard, E J Raynaud

    Acta Paediatrica Scandinavica
    |September 1, 1981
    PubMed
    Summary
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    Enzymatic levels in newborn blood and cerebrospinal fluid (CSF) correlate with psychomotor development. Specific enzymes like ASAT and CK in blood, and LD and HBD in CSF, are key indicators for evaluating neonatal brain injury.

    Area of Science:

    • Neonatal Medicine
    • Biochemistry
    • Developmental Neuroscience

    Background:

    • Neonatal brain injury can have long-term effects on psychomotor development.
    • Accurate and early assessment of neonatal brain injury is crucial for timely intervention.

    Purpose of the Study:

    • To investigate the relationship between enzymatic activities in blood and cerebrospinal fluid (CSF) and psychomotor outcomes in full-term newborn infants.
    • To identify specific enzymatic markers for predicting neonatal brain injury and its impact on development.

    Main Methods:

    • A double-blind study involving 57 full-term newborns.
    • Clinical, electroencephalographical, blood, CSF, and developmental examinations were conducted.
    • Measurement of four enzymatic activities: aminotransferase (ASAT), creatine kinase (CK), lactate dehydrogenase (LD), and hydroxybutyrate dehydrogenase (HBD) in blood and CSF.

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    Main Results:

    • Significant correlations were found between enzymatic levels and psychomotor outcomes.
    • ASAT and CK in blood showed strong relationships with developmental assessments.
    • LD and HBD in CSF were closely linked to psychomotor events at one year of age.
    • Suggested threshold values for blood ASAT and CK were identified.

    Conclusions:

    • Enzymatic analysis in blood and CSF offers a valuable method for evaluating neonatal brain injury.
    • This approach has both theoretical and practical implications for understanding and managing developmental outcomes in newborns.
    • Specific enzyme levels can serve as predictive markers for psychomotor development following neonatal brain injury.