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Transitory congenital hypothyroidism and maternal thyroiditis

E M Ritzén, H Mahler, A Alveryd

    Acta Paediatrica Scandinavica
    |September 1, 1981
    PubMed
    Summary

    Maternal thyroid antibodies can cause congenital hypothyroidism in infants. While one sister required long-term therapy, the other

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    Area of Science:

    • Endocrinology
    • Pediatrics
    • Immunology

    Background:

    • Congenital hypothyroidism (CH) is a common endocrine disorder in newborns.
    • Maternal factors, including autoimmune conditions, can influence fetal thyroid function.

    Observation:

    • Two sisters presented with congenital hypothyroidism.
    • Their mother exhibited high titers of circulating thyroid antibodies during pregnancies.
    • Antibody presence and hypothyroidism severity varied between the sisters.

    Findings:

    • The older sister had partial, persistent hypothyroidism requiring thyroid hormone replacement therapy.
    • The younger sister experienced transient, reversible hypothyroidism, with therapy discontinued after two years.

    Implications:

    • This case highlights the potential for transplacental passage of maternal thyroid antibodies to induce transient or persistent CH.
    • Monitoring thyroid function in infants born to mothers with thyroid autoimmunity is crucial.
    • Understanding the variability in CH presentation is important for clinical management.

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