Related Experiment Videos
Trimethoprim-sulfamethoxazole-induced cholestasis
The American Journal of Gastroenterology
|October 1, 1981
Summary
A woman experienced severe cholestasis after taking trimethoprim-sulfamethoxazole (TMP-SMZ). This case highlights TMP-SMZ as a potential cause of drug-induced liver injury and cholestasis.
Area of Science:
- Pharmacology
- Hepatology
- Toxicology
Background:
- Drug-induced liver injury (DILI) is a significant clinical concern.
- Trimethoprim-sulfamethoxazole (TMP-SMZ) is a commonly prescribed antibiotic with known potential adverse effects.
Observation:
- A 52-year-old female patient presented with severe cholestasis.
- Cholestasis developed seven days post-administration of TMP-SMZ.
Findings:
- The case illustrates a specific instance of liver injury attributed to TMP-SMZ.
- Clinical and pathological features of TMP-SMZ-induced cholestasis are detailed.
Implications:
- This case underscores the importance of considering TMP-SMZ in the differential diagnosis of cholestatic liver injury.
- Understanding the mechanisms of TMP-SMZ hepatotoxicity can guide clinical management and prevention strategies.