[Structural and metabolic changes in the chief gastric glandulocytes in disturbed hormonal balance]

Structural-metabolic changes of the principle cells in the rat gastric glands have been studied electron-microscopically and cytochemically with subsequent cytophotometry during the process of a disturbed pepsin secretion when thyroxin and hydrocortisone are administered. At the experimentally induced hypo- and hyperthyreosis, the gastric juice proteolytic activity is inhibited owing to a decreased energy potential of the principle cell. As ultrastructural analysis has demonstrated, under the conditions mentioned above not only zymogen transport is disturbed, but the release of the mature secretion is also inhibited. Secretory cycle of the principle cell is changed under the effect of hydrocortisone.