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[Age-dependent changes in epitestosterone urinary excretion in man]

G Riondino, F Strollo

    Bollettino Della Societa Italiana Di Biologia Sperimentale
    |November 30, 1981
    PubMed
    Summary

    Epitestosterone (ET) excretion decreases with age, correlating with testosterone (T) but not 17-ketosteroids (17 KS). This suggests ET may originate from testes rather than the adrenal gland.

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    Area of Science:

    • Endocrinology
    • Androgen Metabolism
    • Aging Research

    Context:

    • Previous studies indicated increased urinary epitestosterone (ET) after HCG in older subjects.
    • The origin of ET, often presumed adrenal, remained unclear.
    • Testosterone (T) and 17-ketosteroids (17 KS) excretion patterns change with age.

    Purpose:

    • To investigate epitestosterone (ET) excretion in young adults compared to older individuals.
    • To determine the relationship between ET, testosterone (T), and 17-ketosteroids (17 KS) across different age groups.
    • To explore the potential origin of epitestosterone (ET).

    Summary:

    • Testosterone (T) excretion significantly decreased after age 60, while 17-ketosteroids (17 KS) showed progressive decline with age.
    • Epitestosterone (ET) excretion decreased steadily but not significantly with age.
    • ET correlated well with T under basal and stimulated conditions in all age groups, but ET's response to stimulation correlated with T's response only in younger and presenescent groups, not the elderly.
    • ET's excretion pattern differed from T and significantly from 17 KS.

    Impact:

    • Epitestosterone (ET) excretion declines with age, suggesting a non-adrenal origin.
    • The findings suggest the testis as a potential major source of ET, though other tissues like the liver, prostate, and red blood cells are not excluded.
    • This research contributes to understanding androgen metabolism and aging-related hormonal changes.

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