Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Density and composition models for lipoproteins

J Q Oeswein, P W Chun

    Biophysical Chemistry
    |November 1, 1981
    PubMed
    Summary
    This summary is machine-generated.

    Two new models explain lipoprotein structure using density and composition. Calculations reveal varying lipid distribution in low-density (LDL) and high-density (HDL) lipoproteins, suggesting structural differences.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Thermodynamic molecular switch in macromolecular interactions.

    Cell biochemistry and biophysics·2001
    Same author

    A thermodynamic molecular switch in biological systems: ribonuclease S' fragment complementation reactions.

    Biophysical journal·2000
    Same author

    Application of Planck-Benzinger relationships to biology.

    Methods in enzymology·1998
    Same author

    New thermodynamic studies on ribonuclease A at low pH.

    The Journal of biological chemistry·1995
    Same author

    A turbidimetric method to determine visual appearance of protein solutions.

    Journal of pharmaceutical science and technology : the official journal of PDA·1994
    Same author

    Molecular conformation of ubiquitinated structures and the implications for regulatory function.

    Journal of molecular graphics·1992
    Same journal

    Optimizing grid preparation methods for TEM imaging of amyloid-forming proteins.

    Biophysical chemistry·2026
    Same journal

    Biogenic reduction mechanisms in iron oxide nanoparticle synthesis: Strategies to mitigate microbial resistance.

    Biophysical chemistry·2026
    Same journal

    Novel Pennisetum Alopecuroides-derived activated carbon for high-efficiency Tartrazine Removal: Box-Behnken optimization and DFT-assisted mechanistic insights.

    Biophysical chemistry·2026
    Same journal

    Reactive molecular dynamics investigation of the first steps of coronavirus (COVID-19) viral-protein ligands fragment (SARS-CoV-2).

    Biophysical chemistry·2026
    Same journal

    Probing the interactions between bovine hemoglobin and three berberine saturated fatty acid salts by multi-spectral techniques, conductimetry and molecular docking.

    Biophysical chemistry·2026
    Same journal

    Insights from NMR - based metabolomics elucidates key metabolic dysregulation in pancreatitis-induced acute respiratory distress syndrome: A step towards precision medicine.

    Biophysical chemistry·2026
    See all related articles

    Area of Science:

    • Biochemistry
    • Structural Biology
    • Lipid Metabolism

    Background:

    • Lipoprotein structure is crucial for lipid transport and cardiovascular health.
    • Existing models, including space-filling and boundary-defined approaches, offer different perspectives on lipoprotein organization.
    • Understanding the precise arrangement of lipids and proteins within lipoproteins is essential for interpreting their function.

    Purpose of the Study:

    • To propose and evaluate two theoretical models for lipoprotein particle structure.
    • To compare these models with existing space-filling and boundary-defined models.
    • To investigate the distribution of apolar lipids within different lipoprotein classes.

    Main Methods:

    • Utilized analytical ultracentrifugation to determine the Stokes' coefficient.

    Related Experiment Videos

  • Employed the Maude-Whitemore expression for calculations.
  • Developed theoretical models based on lipoprotein density and composition.

    • Main Results:

    • Calculated the percentage of total apolar lipid in the hydrophobic core for LDL (28%), HDL2 (64%), and HDL3 (94%).
    • Demonstrated significant differences in lipid accommodation across lipoprotein classes.
    • Indicated potential variations in cholesteryl ester and triglyceride packing.

    Conclusions:

    • The proposed density and composition models provide insights into lipoprotein structure.
    • Findings suggest distinct packing of lipids and conformations of apolipoproteins among LDL, HDL2, and HDL3.
    • These structural differences may influence lipoprotein function and metabolism.