[Correlation of hemodynamic changes and mesenteric microcirculation in response to electric stimulation of the celiac...

Acute experiments on anesthetized rats were made to study the time course of cardiac output (Cardiogreen dilution method) and systemic arterial pressure during electrical stimulation of the celiac ganglion. In other series of experiments a study was made of the time course of microcirculatory changes in the mesentery under the same conditions and with the use of intravital microscopy. An appreciable increase in the minute volume (23.44 +/- 4.91) was revealed 6 s after the onset of the stimulation. The increase in arterial pressure amounted to 7.06 +/- 2.45%. The increase of arterial pressure in the second series of experiments was 18.8 +/- 2.2%, and vasoconstriction 4.1 +/- 1.6% (the initial diameter of the vessels being 264.59 +/- 4.50 micrometers). Celiac ganglion stimulation led to a progressive deceleration of the blood flow and stoppage of the blood flow, with the diameter of the microvessels remaining unchanged. Regression analysis of the data obtained allows the conclusion that microcirculatory changes seen in the mesentery and initial hypertensive response are consequent on the increased cardiac output, on the one hand, and on the constriction of the mesenterial vessels, on the other.