[Formation of a generator of pathologically enhanced excitation in the caudate nucleus in experimental parkinsonism]

Rats with the Parkinsonian syndrome induced by administering tetanus toxin to the rostral part of both the caudate nuclei manifest an increased electrical activity in this part. The increase is marked by the rise of the number of points where the neuronal activity is recordable, by a greater frequency of the background impulse activity of the neurons and by the appearance of the neurons with packet activity. The data obtained allow the conclusion that administration of tetanus toxin that disturbs the inhibition mechanisms including dopamine secretion results in the formation of the caudate nuclei of the generator of pathologically enhanced excitation which seems likely to form the neuropathophysiological basis of the Parkinsonian syndrome.