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Related Experiment Videos

Oral methotrexate therapy for multiple superficial bladder carcinomata

R R Hall, D W Herring, A C McGill

    Cancer Treatment Reports
    |January 1, 1981
    PubMed
    Summary

    Weekly methotrexate (MTX) syrup effectively reduced tumor recurrence in patients with bladder cancer. This treatment achieved cytotoxic drug levels, offering a promising option for managing frequent bladder carcinoma recurrences.

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    Area of Science:

    • Urology
    • Oncology
    • Pharmacology

    Background:

    • Bladder cancer, specifically multiple class T1 carcinomata, frequently recurs in patients.
    • Managing recurrent bladder tumors requires effective and tolerable treatment strategies.

    Purpose of the Study:

    • To evaluate the efficacy of weekly oral methotrexate (MTX) in reducing tumor recurrence in patients with frequently recurring T1 bladder carcinomata.
    • To confirm that the administered dose of MTX achieves cytotoxic concentrations in urine.

    Main Methods:

    • Patients received 50 mg of methotrexate (MTX) in syrup orally once per week.
    • Tumor recurrence frequency and number were monitored.
    • Methotrexate (MTX) levels were measured in urine samples to assess drug concentration.

    Main Results:

    • 16 out of 17 patients experienced a reduction in the frequency and number of tumor recurrences.
    • Urine methotrexate (MTX) level measurements indicated cytotoxic concentrations for at least 24 hours post-administration.

    Conclusions:

    • Weekly oral methotrexate (MTX) is an effective treatment for reducing recurrence in patients with T1 bladder carcinomata.
    • The 50 mg weekly dose of MTX achieves therapeutic drug levels, supporting its use in managing recurrent bladder cancer.

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