Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Antibiotic prophylaxis in genitourinary surgery

S J Childs, P D Wood, J W Kosola

    Clinical Therapeutics
    |January 1, 1981
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    An improved temporal formulation of pupal transpiration in Glossina.

    Mathematical biosciences·2015
    Same author

    A model of teneral dehydration in Glossina.

    Acta tropica·2013
    Same author

    A set of discrete formulae for the performance of a tsetse population during aerial spraying.

    Acta tropica·2012
    Same author

    Neuronal expression of class 6 semaphorins in zebrafish.

    Gene expression patterns : GEP·2012
    Same author

    Theoretical levels of control as a function of mean temperature and spray efficacy in the aerial spraying of tsetse fly.

    Acta tropica·2010
    Same author

    The finite element implementation of a K.P.P. equation for the simulation of tsetse control measures in the vicinity of a game reserve.

    Mathematical biosciences·2010
    Same journal

    Early Feasibility Studies in Europe: A Multisite Qualitative Study of Operational Challenges and Site Selection Determinants at 6 University Hospitals.

    Clinical therapeutics·2026
    Same journal

    Safety of Celecoxib in Elderly Patients With Osteoarthritis: A Real-World Analysis Based on the FAERS Database.

    Clinical therapeutics·2026
    Same journal

    Reimagining Representation Across the Clinical Research Ecosystem: Part II of a Specialty Update on Advancing Diversity, Racial Equity, and Inclusion in Clinical Research.

    Clinical therapeutics·2026
    Same journal

    Combined Effects of Nicorandil and Enhanced External Counterpulsation on Coronary Microcirculation and Exercise Capacity in Patients With Coronary Slow Flow Phenomenon: A Randomized, Controlled, 3-Arm Trial.

    Clinical therapeutics·2026
    Same journal

    Phase 1 Study Evaluating Gefurulimab Pharmacokinetics and Safety Following Delivery Via Autoinjector or Prefilled Syringe With Needle Safety Device in Healthy Adults.

    Clinical therapeutics·2026
    Same journal

    Evaluating Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis Associated With Newer Antiseizure Medications Using FAERS and JADER Combined With Bioinformatics Exploration.

    Clinical therapeutics·2026
    See all related articles

    Antibiotic prophylaxis in genitourinary surgery may reduce short-term infections like bacteriuria. Cefotaxime showed a lower infection rate than cefazolin in a comparative study.

    Area of Science:

    • Urology
    • Infectious Diseases
    • Surgical Prophylaxis

    Background:

    • The efficacy of antibiotic prophylaxis in genitourinary surgery remains debated.
    • Previous studies often lacked rigorous experimental design, yielding testimonial rather than scientific evidence.
    • Current literature suggests potential benefits for short-term postoperative bacteriuria and bacteremia, without increasing resistant infections.

    Purpose of the Study:

    • To evaluate the effectiveness of antibiotic prophylaxis in elective genitourinary surgery.
    • To compare the efficacy of cefazolin versus cefotaxime for antibiotic prophylaxis in this setting.

    Main Methods:

    • A comparative study involving 160 evaluable cases undergoing elective genitourinary surgery.
    • Patients received either cefazolin or cefotaxime with identical perioperative dosage regimens, not exceeding 24 hours postoperatively.

    Related Experiment Videos

  • Postoperative cultures were monitored for the first nine days.

    • Main Results:

    • A total of 23 patients (14.4%) had positive cultures within nine days post-surgery.
    • Only two infections occurred within the first five days.
    • The infection rate was 19% for cefazolin compared to 10% for cefotaxime.

    Conclusions:

    • Antibiotic prophylaxis, when administered perioperatively for no more than 24 hours, appears to have merit in elective genitourinary surgery.
    • Cefotaxime demonstrated a lower infection rate than cefazolin in this comparative trial.
    • Further research may refine optimal antibiotic choices and durations for surgical prophylaxis.