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Carnosine levels in blood

J E Seely, F D Marshall

    Experientia
    |December 15, 1981
    PubMed
    Summary
    This summary is machine-generated.

    Carnosine is present in chick erythrocytes and plasma, with higher concentrations found in reticulocytes compared to normal blood cells in rabbits. This study quanties carnosine levels across different species and blood components.

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    Area of Science:

    • Biochemistry
    • Comparative physiology
    • Cellular biology

    Background:

    • Carnosine is a dipeptide with known antioxidant and buffering properties.
    • Its distribution and concentration in various animal tissues and cell types require further elucidation.
    • Understanding carnosine levels can provide insights into cellular metabolic processes.

    Purpose of the Study:

    • To quantify carnosine levels in chick erythrocytes and plasma.
    • To compare carnosine concentrations in different blood components of rabbits, including reticulocytes and normal blood cells.
    • To determine carnosine levels in rat and rabbit blood.

    Main Methods:

    • Spectrophotometric assays were employed to measure carnosine concentrations.
    • Samples analyzed included chick erythrocytes, chick plasma, rat blood, rabbit blood, rabbit reticulocyte-rich blood, normal rabbit blood, and rabbit bone marrow.

    Main Results:

    • Chick erythrocytes contained high carnosine levels (2510 nmoles/g cells).
    • Chick plasma showed lower carnosine concentrations (27 nmoles/ml).
    • Rabbit reticulocyte-rich blood had significantly higher carnosine (105 nmoles/g cells) compared to normal rabbit blood (18 nmoles/g cells).

    Conclusions:

    • Carnosine is a significant component of chick erythrocytes.
    • Reticulocytes exhibit higher carnosine content than mature erythrocytes in rabbits.
    • Species-specific variations in carnosine distribution exist within blood components.