Inflammation in relation to dietary intake of zinc and copper

The role of the trace metal copper (Cu) and the role of the trace metal zinc (Zn) in inflammation were studied in rats fed diets containing varying amounts of these metals. Rats fed a diet low in Cu for two months developed more carrageenin induced inflammation than did control rats eating normal food. In rats eating the low Cu diet supplemented by added Cu, inflammation was reduced to normal levels. Rats fed a diet low in Zn for three months developed more footpad swelling after challenge with carrageenin and with monosodium urate crystals than did control rats eating a normal diet.