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A pharmacokinetic analysis program (multi) for microcomputer

K Yamaoka, Y Tanigawara, T Nakagawa

    Journal of Pharmacobio-Dynamics
    |November 1, 1981
    PubMed
    Summary
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    A new nonlinear least squares program (MULTI) was developed for microcomputers, enabling simultaneous fitting of pharmacokinetic equations to patient data. This tool enhances the analysis of drug concentration-time profiles.

    Area of Science:

    • Pharmacokinetics and Pharmacometry
    • Computational Chemistry
    • Software Development

    Background:

    • Accurate pharmacokinetic modeling is crucial for understanding drug behavior in the body.
    • Existing software for nonlinear curve fitting may lack flexibility or be inaccessible on microcomputers.
    • The MULTI program addresses the need for a user-friendly, versatile tool for pharmacokinetic analysis.

    Purpose of the Study:

    • To develop and present a nonlinear least squares program (MULTI) for microcomputers.
    • To implement multiple algorithms for robust nonlinear curve fitting.
    • To facilitate simultaneous fitting of user-defined pharmacokinetic equations to experimental data.

    Main Methods:

    • Development of the MULTI program in BASIC for microcomputer accessibility.

    Related Experiment Videos

  • Integration of four distinct nonlinear least squares algorithms: Gauss-Newton, damped Gauss-Newton, modified Marquardt, and simplex methods.
  • Capability for simultaneous fitting of up to five user-defined pharmacokinetic models.
  • Demonstration using real-world pharmacokinetic data for ampicillin and oxacillin in humans.

    • Main Results:

    • Successful development of the MULTI program, offering a flexible platform for pharmacokinetic analysis.
    • Validation of the program's performance through application to ampicillin and oxacillin time-course data.
    • Demonstrated ability to simultaneously fit multiple pharmacokinetic equations to observed data.

    Conclusions:

    • The MULTI program provides an effective and accessible solution for nonlinear pharmacokinetic modeling on microcomputers.
    • The software's flexibility in algorithm choice and model definition supports diverse analytical needs.
    • MULTI facilitates the analysis of drug disposition kinetics, aiding in clinical pharmacology research.