Lower gastrointestinal side effects of nonsteroidal antiinflammatory drugs

It has been well accepted that the nonsteroidal antiinflammatory drugs (NSAID) can cause upper gastrointestinal (GI) blood loss and reactivation of peptic ulcer disease. This report describes 3 patients in whom the ingestion of a NSAID was temporally associated with serious lower GI disease, including bleeding in 2 patients. These cases suggest an association between NSAID and activation of serious lower GI disease.