Metioprim-sulphadiazine distribution in the canine prostate

Constant infusion experiments with metioprim and sulphadiazine were performed in four anesthesized dogs to determine the drugs' concentrations in prostatic secretion, prostatic interstitial fluid, prostatic tissue, urine, and serum. Metioprim showed a specific affinity for the prostate gland, whereas sulphadiazine, as expected, demonstrated lower values in prostatic secretion and tissue than in serum. The prostatic secretion:serum and prostatic tissue:serum ratios using a high-pressure liquid chromatography assay of metioprim were 7.3 and 4.0, respectively. Furthermore, metioprim showed 3.6 to 5.7 times higher concentrations in the organs of the urogenital system, liver, lung, and pancreas than in serum. We suggest that metioprim may be useful in the treatment of bacterial prostatis, considering its spectrum of antibacterial activity and the data presented in this study.