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Related Experiment Videos

Esophageal motility and pulmonary function in progressive systemic sclerosis

P Denis, P Ducrotte, P Pasquis

    Respiration; International Review of Thoracic Diseases
    |January 1, 1981
    PubMed
    Summary

    Esophageal dysfunction, particularly impaired peristalsis and lower esophageal sphincter (LES) function, is linked to reduced lung function in progressive systemic sclerosis (PSS). Gastroesophageal reflux (GER) may worsen pulmonary fibrosis in these patients.

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    Area of Science:

    • Pulmonary Medicine
    • Gastroenterology
    • Rheumatology

    Background:

    • Progressive systemic sclerosis (PSS) is an autoimmune disease affecting multiple organs.
    • Esophageal dysfunction is common in PSS and can impact lung health.
    • The relationship between esophageal motility and lung function abnormalities in PSS requires further investigation.

    Purpose of the Study:

    • To evaluate the influence of esophageal dysfunction on lung function abnormalities in patients with PSS.
    • To compare pulmonary function tests based on different degrees of esophageal motility in PSS patients.

    Main Methods:

    • Pulmonary function tests were conducted on 24 patients with PSS.
    • Patients were categorized into three groups based on esophageal motility: normal, impaired peristalsis with normal lower esophageal sphincter (LES), and impaired peristalsis with LES dysfunction.

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  • Dynamic lung compliance was measured and compared across the groups.

    • Main Results:

    • Dynamic lung compliance was significantly lower in patients with impaired peristalsis and LES function compared to those with normal motility or only impaired peristalsis.
    • This finding suggests a potential link between severe esophageal dysfunction and reduced lung function.

    Conclusions:

    • Impaired esophageal motility, especially involving both peristalsis and LES function, is associated with significant lung function abnormalities in PSS.
    • Gastroesophageal reflux (GER), potentially exacerbated by impaired LES function, may contribute to the progression of pulmonary fibrosis in PSS.