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Sinusoidal fetal heart rate pattern associated with alphaprodine administration
Obstetrics and Gynecology
|December 1, 1978
Summary
Alphaprodine (Nisentil) use during labor was associated with sinusoidal fetal heart rate patterns in 42.5% of women. These patterns appeared shortly after administration and did not negatively impact Apgar scores.
Area of Science:
- Obstetrics
- Pharmacology
- Fetal Monitoring
Background:
- Labor pain management often involves analgesics.
- Fetal heart rate (FHR) monitoring is crucial during labor.
- Sinusoidal FHR patterns can indicate fetal distress.
Purpose of the Study:
- To investigate the incidence of sinusoidal FHR patterns following alphaprodine administration.
- To determine the timing and duration of these patterns.
- To assess the impact of sinusoidal FHR patterns on neonatal outcomes.
Main Methods:
- Observational study of 40 women receiving alphaprodine for labor pain.
- Comparison with a control group of 18 women not receiving narcotic analgesia.
- Analysis of FHR patterns and Apgar scores.
Main Results:
- Sinusoidal FHR patterns occurred in 42.5% of women receiving alphaprodine.
- Patterns emerged ~19 minutes post-administration and lasted ~60 minutes.
- Most neonates with sinusoidal FHR had Apgar scores ≥7; exceptions were linked to delivery complications.
Conclusions:
- Alphaprodine is associated with a significant incidence of sinusoidal FHR patterns.
- These patterns, while notable, did not appear to cause adverse neonatal outcomes in this cohort.
- Further research may be warranted to understand the mechanism and clinical significance.