Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Ventricular size and intelligence in achondroplasia

B L Priestley, J Lorber

    Zeitschrift Fur Kinderchirurgie : Organ Der Deutschen, Der Schweizerischen Und Der Osterreichischen Gesellschaft Fur Kinderchirurgie = Surgery in Infancy and Childhood
    |December 1, 1981
    PubMed
    Summary

    Children with achondroplasia and macrocephaly typically have normal intelligence. While some cases of hydrocephalus require intervention, most children with achondroplasia and megalencephaly exhibit normal neurological and intellectual development.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Use, timing and factors associated with tracheal intubation in septic shock: a prospective multicentric observational study.

    Annals of intensive care·2020
    Same author

    A Controlled Trial of Immediate and Delayed Closure of Spina Bifida Cystica.

    Archives of disease in childhood·2010
    Same author

    The Changing Ætiology of Erythema Nodosum in Children [Summary].

    Proceedings of the Royal Society of Medicine·2009
    Same author

    The Follow-up of Children with Tuberculous Meningitis with Special Reference to Psychiatric and Neurological Aspects [Abstract].

    Proceedings of the Royal Society of Medicine·2009
    Same author

    Congenital Absence of the Corpus Callosum.

    Proceedings of the Royal Society of Medicine·2009
    Same author

    What impact have women physicians had on women's health?

    Journal of the American Medical Women's Association (1972)·2000

    Area of Science:

    • Pediatric Neurology
    • Medical Genetics
    • Developmental Pediatrics

    Background:

    • Achondroplasia is the most common form of skeletal dysplasia.
    • Macrocephaly, an enlarged head circumference, can be associated with various genetic conditions.
    • The neurological and intellectual outcomes in children with achondroplasia and macrocephaly require further investigation.

    Purpose of the Study:

    • To investigate the neurological and intellectual development in children with achondroplasia and macrocephaly.
    • To determine the incidence of hydrocephalus in this patient cohort.
    • To assess the impact of hydrocephalus treatment on neurodevelopmental outcomes.

    Main Methods:

    • Retrospective case series analysis of 10 children with achondroplasia and macrocephaly.

    Related Experiment Videos

  • Neurological and intellectual assessments were performed.
  • Hydrocephalus was diagnosed and managed with shunt procedures when indicated.

    • Main Results:

    • Two out of 10 children presented with progressive hydrocephalus, requiring shunt placement.
    • Outcomes for treated hydrocephalus varied: one child was normal, another had severe disability.
    • Mild ventricular dilatation was observed in three children; one died from foramen magnum stenosis.
    • The majority of children, including those with megalencephaly, demonstrated normal intellectual and neurological development.

    Conclusions:

    • Intelligence in achondroplasia is predominantly within the normal range.
    • Macrocephaly in achondroplasia is not consistently associated with adverse neurological or intellectual outcomes.
    • Careful monitoring for hydrocephalus and foramen magnum stenosis is warranted in this population.