The effect of carbonic anhydrase inhibition on central corneal thickness after cataract extraction

The influence of acetazolamide (a carbonic anhydrase inhibitor) on central thickness of the human cornea in vivo was studied. Corneal thickness as measured after cataract surgery was significantly increased by acetazolamide, if the specular microscopy revealed central corneal guttae, pre-operatively. When no guttae were seen by specular microscopy, no effect could be demonstrated.