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Hemoperfusion in quinidine intoxication
Acta Medica Scandinavica
|January 1, 1981
Summary
Charcoal hemoperfusion effectively treated severe quinidine intoxication. This method significantly reduced serum quinidine levels and normalized clinical and ECG signs, suggesting it as a primary treatment option.
Area of Science:
- Cardiology
- Clinical Toxicology
- Pharmacology
Background:
- Quinidine is an antiarrhythmic medication with a narrow therapeutic index.
- Overdose can lead to severe cardiotoxicity and neurological effects.
- Standard treatments may not rapidly eliminate quinidine in severe cases.
Observation:
- A patient ingested 8.1 g of quinidine, presenting with severe intoxication signs and a high serum quinidine level (8.5 mg/L).
- The patient underwent six hours of charcoal hemoperfusion.
- Clinical and electrocardiogram (ECG) abnormalities were monitored throughout the treatment.
Findings:
- Charcoal hemoperfusion reduced serum quinidine levels by an average of 36%.
- The mean quinidine clearance achieved with hemoperfusion was 24 ml/min.
- All clinical and ECG signs of quinidine intoxication resolved during hemoperfusion.
Implications:
- Charcoal hemoperfusion is a highly effective method for managing severe quinidine intoxication.
- This treatment modality offers rapid reduction of quinidine levels and clinical improvement.
- Hemoperfusion should be considered a primary therapeutic option in severe quinidine overdose cases.